CovidChloroV1, Main, Exploration, bibRecord, 000202

Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials.

Identifieur interne : 000202 ( Main/Exploration ); précédent : 000201; suivant : 000203

Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials.

Auteurs : Van Thu Nguyen [France] ; Philippe Rivière [France] ; Pierre Ripoll [France] ; Julien Barnier [France] ; Romain Vuillemot [France] ; Gabriel Ferrand [France] ; Sarah Cohen-Boulakia [France] ; Philippe Ravaud [France] ; Isabelle Boutron [France]

Source :

Journal of clinical epidemiology [ 1878-5921 ] ; 2021.

RBID : pubmed:33096223

Descripteurs français

KwdFr :
- Cartographie géographique (MeSH), Essais contrôlés randomisés comme sujet (MeSH), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Internet (MeSH), Italie (MeSH), Mâle (MeSH), Méthodologie en recherche épidémiologique (MeSH), Pandémies (prévention et contrôle), Taille de l'échantillon (MeSH), États-Unis (MeSH).
MESH :
- prévention et contrôle : Pandémies.
- usage thérapeutique : Hydroxychloroquine.
- Cartographie géographique, Essais contrôlés randomisés comme sujet, Femelle, Humains, Internet, Italie, Mâle, Méthodologie en recherche épidémiologique, Taille de l'échantillon, États-Unis.
Wicri :
- geographic : Italie, États-Unis.

English descriptors

KwdEn :
- COVID-19 (drug therapy), COVID-19 (prevention & control), Epidemiologic Research Design (MeSH), Female (MeSH), Geographic Mapping (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Internet (MeSH), Italy (MeSH), Male (MeSH), Pandemics (prevention & control), Randomized Controlled Trials as Topic (MeSH), Sample Size (MeSH), United States (MeSH).
MESH :
- chemical , therapeutic use : Hydroxychloroquine.
- geographic : Italy, United States.
- drug therapy : COVID-19.
- prevention & control : COVID-19, Pandemics.
- Epidemiologic Research Design, Female, Geographic Mapping, Humans, Internet, Male, Randomized Controlled Trials as Topic, Sample Size.

Abstract

OBJECTIVES

Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated.

STUDY DESIGN AND SETTING

We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered.

RESULTS

By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients.

CONCLUSION

This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed.

DOI: 10.1016/j.jclinepi.2020.10.010
PubMed: 33096223
PubMed Central: PMC7575422

Affiliations:

France
Auvergne-Rhône-Alpes, Rhône-Alpes, Île-de-France
Lyon, Orsay, Paris, Villeurbanne, Écully

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000958
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Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY DESIGN AND SETTING</b>
</p>
<p>We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed.</p>
</div>
</front>
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<Abstract><AbstractText Label="OBJECTIVES">Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated.</AbstractText>
<AbstractText Label="STUDY DESIGN AND SETTING">We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered.</AbstractText>
<AbstractText Label="RESULTS">By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients.</AbstractText>
<AbstractText Label="CONCLUSION">This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Van Thu</ForeName>
<Initials>VT</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Centre of Research Epidemiology and Statistics (CRESS), Inserm, F-75004 Paris, France; Cochrane France, AP-HP, 75004 Paris, France. Electronic address: van.nguyen@clinicalepidemio.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rivière</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>VisionsCarto, France; Ecole Centrale Lyon, LIRIS CNRS, 69134 Écully, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ripoll</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>INSA Lyon, LIRIS CNRS, 69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barnier</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre Max Weber, CNRS, 69007 Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vuillemot</LastName>
<ForeName>Romain</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Ecole Centrale Lyon, LIRIS CNRS, 69134 Écully, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferrand</LastName>
<ForeName>Gabriel</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Cochrane France, AP-HP, 75004 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cohen-Boulakia</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Recherche en Informatique (LRI), Université Paris-Saclay, CNRS, 91405 Orsay, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ravaud</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Centre of Research Epidemiology and Statistics (CRESS), Inserm, F-75004 Paris, France; Cochrane France, AP-HP, 75004 Paris, France; Centre d'Epidémiologie Clinique, Hôpital Hôtel Dieu, Assistance Publique des Hôpitaux de Paris (APHP), F-75004 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boutron</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Centre of Research Epidemiology and Statistics (CRESS), Inserm, F-75004 Paris, France; Cochrane France, AP-HP, 75004 Paris, France; Centre d'Epidémiologie Clinique, Hôpital Hôtel Dieu, Assistance Publique des Hôpitaux de Paris (APHP), F-75004 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>COVID-NMA Consortium Team</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>10</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Clin Epidemiol</MedlineTA>
<NlmUniqueID>8801383</NlmUniqueID>
<ISSNLinking>0895-4356</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015340" MajorTopicYN="N">Epidemiologic Research Design</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062305" MajorTopicYN="N">Geographic Mapping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020407" MajorTopicYN="N">Internet</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018401" MajorTopicYN="N">Sample Size</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Clinical trial</Keyword>
<Keyword MajorTopicYN="Y">Living mapping</Keyword>
<Keyword MajorTopicYN="Y">Meta-analysis</Keyword>
<Keyword MajorTopicYN="Y">Prevention</Keyword>
<Keyword MajorTopicYN="Y">Systematic review</Keyword>
<Keyword MajorTopicYN="Y">Treatment</Keyword>
</KeywordList>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Alawadhi</LastName>
<ForeName>Solaf</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Amer-Yahia</LastName>
<ForeName>Sihem</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Informatique de Grenoble (LIG), CNRS, 38401 Saint-Martin-d'Hères, France.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Ávila</LastName>
<ForeName>Camila</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Epistemonikos Foundation, Chile.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Bafeta</LastName>
<ForeName>Aïda</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Baudry</LastName>
<ForeName>Julia</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Eren Team, 75013, Paris, France.</Affiliation>
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<Investigator ValidYN="Y"><LastName>Bollig</LastName>
<ForeName>Claudia</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Cochrane Germany, Cochrane Germany Foundation, 79110, Freiburg, Germany.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Bonnet</LastName>
<ForeName>Hillary</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Université de Paris, 75006, Paris, France; Bordeaux Pharmacoepi - ADERA, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Boutron</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bouet</LastName>
<ForeName>Marinette</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Université Clermont Auvergne, CNRS, 63178 Aubiere, France.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Cabanac</LastName>
<ForeName>Guillaume</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Université Toulouse 3 - Paul Sabatier - Institut de Recherche en Informatique de Toulouse - IRIT UMR 5505, 31062 Toulouse, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chaimani</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chavalarias</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institut des Systèmes Complexes de Paris IDF (ISC-PIF), CNRS, 75013, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yaolong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>WHO Collaborating Centre for Guideline Implementation and Knowledge Translation & Chinese GRADE Centre, Lanzhou University, 730000, Gansu, China.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chevance</LastName>
<ForeName>Astrid</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cohen-Boulakia</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Recherche en Informatique (LRI), University Paris-Saclay, CNRS, 91405, Orsay, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Coquery</LastName>
<ForeName>Emmanuel</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Conil</LastName>
<ForeName>Francoise</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Davidson</LastName>
<ForeName>Mauricia</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>De Nale</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Devane</LastName>
<ForeName>Declan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Evidence Synthesis Ireland & Cochrane Ireland, National University of Ireland, Galway, Ireland.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Diard</LastName>
<ForeName>Elise</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Doreau</LastName>
<ForeName>Bastien</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Université Clermont Auvergne, CNRS, 63178 Aubiere, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Evrenoglou</LastName>
<ForeName>Theodoros</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fabri</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre for Evidence Based Medicine Odense (CEBMO), University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Feron</LastName>
<ForeName>Gilles</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>French National Research Institute for Agriculture, Food and Environment (INRAE), 75338, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ferrand</LastName>
<ForeName>Gabriel</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fezeu</LastName>
<ForeName>Leopold</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Eren Team, 75013, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fouet</LastName>
<ForeName>Mathilde</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Service de Neurochirurgie, Hôpital d'Instruction des Armées Percy (HIA), 92140, Clamart, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>El Chall</LastName>
<ForeName>Lina Ghosn</ForeName>
<Initials>LG</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Graña</LastName>
<ForeName>Carolina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Grasselli</LastName>
<ForeName>Giacomo</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Adult Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, 20122, Milano, Italy.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Grolleau</LastName>
<ForeName>François</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hacid</LastName>
<ForeName>Mohand-Said</ForeName>
<Initials>MS</Initials>
<AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Haddy</LastName>
<ForeName>Loubna</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Sanofi, 91380, Chilly-Mazarin, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hansen</LastName>
<ForeName>Camilla</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre for Evidence Based Medicine Odense (CEBMO), University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hohlfeld</LastName>
<ForeName>Ameer</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Cochrane South Africa, South African Medical Research Council, 7505 Tygerberg, South Africa.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hróbjartsson</LastName>
<ForeName>Asbjørn</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre for Evidence Based Medicine Odense (CEBMO), University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Julia</LastName>
<ForeName>Chantal</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Eren Team, 75013, Paris, France.</Affiliation>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Mavridis</LastName>
<ForeName>Dimitris</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Primary Education, University of Ioannina, 45110, Ioannina, Greece.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Meerpohl</LastName>
<ForeName>Joerg J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Cochrane Germany, Cochrane Germany Foundation, 79110, Freiburg, Germany; Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, 79110, Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Meyer</LastName>
<ForeName>Brice</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, 79110, Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Naidoo</LastName>
<ForeName>Nivantha</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Thu</LastName>
<ForeName>Van Nguyen</ForeName>
<Initials>VN</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Oikonomidi</LastName>
<ForeName>Theodora</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pienaar</LastName>
<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Cochrane South Africa, South African Medical Research Council, 7505 Tygerberg, South Africa.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Quirke</LastName>
<ForeName>Fiona</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Health Research Board-Trials Methodology Research Network (HRB-TMRN), NUI Galway, Ireland.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rada</LastName>
<ForeName>Gabriel</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Institut des Systèmes Complexes de Paris IDF (ISC-PIF), CNRS, 75013, Paris, France; Cochrane Chile, Evidence-Based Centre, Pontificia Universidad Católica de Chile, Santiago, Santiago Metropolitan Region, Chile.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ravaud</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ripoll</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Riveros</LastName>
<ForeName>Carolina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rivière</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sauvant</LastName>
<ForeName>Marie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Université Clermont Auvergne, CNRS, 63178 Aubiere, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schmucker</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, 79110, Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Toumani</LastName>
<ForeName>Farouk</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Université Clermont Auvergne, CNRS, 63178 Aubiere, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tovey</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France; Université de Paris, 75006, Paris, France; Cochrane France, 75004, Paris, France.</Affiliation>
</AffiliationInfo>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vuillemot</LastName>
<ForeName>Romain</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
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Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials.

Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials.

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